BD-PM4156

VEGFA (PT0865) Mouse Monoclonal Antibody

VEGFA; VEGF; Vascular endothelial growth factor A; VEGF-A; Vascular permeability factor; VPF

常规抗体

VEGFA

Vascular endothelial growth factor A

WB

Human

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

7422

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7422

P15692

http://www.uniprot.org/uniprotkb/P15692/entry

22339

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22339

Q00731

http://www.uniprot.org/uniprot/Q00731

83785

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83785

P16612

http://www.uniprot.org/uniprot/P16612

VEGF-A Antibody detects endogenous levels of human VEGF-A protein.. The antibody was also Predict react with Mouse;Rat

WB 1:500-2000

21kD(monomer),42kD(dimer)

-15°C to -25°C/1 year(Do not lower than -25°C)

Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland.

Secreted . VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a significant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.

Cytokine-cytokine receptor interaction;mTOR;VEGF;Focal adhesion;Pathways in cancer;Renal cell carcinoma;Pancreatic cancer;Bladder cancer;

function:Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Binds to the VEGFR1/Flt-1 and VEGFR2/Kdr receptors, heparan sulfate and heparin. Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to VEGFR2/Kdr but doesn't activate downstream signaling pathways, doesn't activate angiogenesis and inhibits tumor growth.,induction:Regulated by growth factors, cytokines, gonadotropins, nitric oxide, hypoxia, hypoglycemia and oncogenic mutations.,online information:VEGF entry,similarity:Belongs to the PDGF/VEGF growth factor family.,subcellular location:VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.,subunit:Homodimer; disulfide-linked. Also found as heterodimer with PlGF.,tissue specificity:The VEGF189, VEGF-165 and VEGF-121 isoforms are widely expressed, whereas the VEGF206 and VEGF-145 are uncommon.,

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