BD-PN1082

KCNE3 Rabbit Polyclonal Antibody

常规抗体

KCNE3

Potassium voltage-gated channel subfamily E member 3 (MinK-related peptide 2) (Minimum potassium ion channel-related peptide 2) (Potassium channel subunit beta MiRP2)

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

10008

Q9Y6H6

https://www.uniprot.org/uniprotkb/Q9Y6H6/entry

Q9WTW2

http://www.uniprot.org/uniprot/Q9WTW2

Q9JJV7

http://www.uniprot.org/uniprot/O54941Q9JJV7

Synthesized peptide derived from human protein . at AA range: 30-110

KCNE3 Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000 ELISA 1:5000-20000

11kD

-20°C/1 year

Polyclonal, Rabbit,IgG

potassium voltage-gated channel subfamily E regulatory subunit 3(KCNE3) Homo sapiens Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis. [provided by RefSeq, Jul 2008],

Expressed in hippocampal neurons (at protein level) (PubMed:12954870). Widely expressed with highest levels in kidney and moderate levels in small intestine.

Cell membrane ; Single-pass type I membrane protein . Cytoplasm . Perikaryon . Cell projection, dendrite . Membrane raft . Colocalizes with KCNB1 at high-density somatodendritic clusters on the surface of hippocampal neurons. .

disease:Defects in KCNE3 are a cause of periodic paralysis hypokalemic (HOKPP) [MIM:170400]; also designated HYPOPP. HOKPP is an autosomal dominant disorder manifested by episodic flaccid generalized muscle weakness associated with falls of serum potassium levels.,disease:Defects in KCNE3 are a cause of thyrotoxic hypokalemic periodic paralysis (TPP) [MIM:188580]. TPP is seen in individuals of all races and manifests as attacks of episodic weakness with hypokalemia during thyrotoxicosis. TPP is seen most commonly in young Latin American or Asian men where up to 10% of thyrotoxic patients may have periodic paralysis. In such patients thyrotoxicosis has often been overlooked for many months. TPP generally occurs as a sporadic disease, and the periodic paralysis resolves completely with treatment of the thyrotoxicosis, although the muscle phenotype returns if the patient becomes thyrotoxic again later.,function:Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion.,similarity:Belongs to the potassium channel KCNE family.,subunit:Associates with KCNC4/Kv3.4. May associate with KCNQ1/KCLQT1.,tissue specificity:Widely expressed with highest levels in kidney and moderate levels in small intestine.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.