RM7236

Phospho-IKB alpha (Y42) (19B14) Rabbit Monoclonal Antibody

IKBA; IKBalpha; MAD3; NFKBI; NFKBIA;

Affinity-chromatography

常规抗体

NFKBIA

IKBA, MAD3, NFKBI

WB

Human

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

4792

P25963

WB 1:500~1:2000

36kDa

Rabbit IgG

Phospho-IKB alpha (Y42) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

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