产品名称
Phospho-eIF4EBP1 (T70) (11B3) Rabbit Monoclonal Antibody
别名
4EBP1; eIF4E binding protein 1; Eif4ebp1; PHASI;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q13541
免疫原
A synthetic peptide of human eIF4EBP1
稀释度
WB: 1:1000 IHC: 1:100-1:200 ICC/IF: 1:200-1500 FC: 1:20 IP: 1:20
注意事项
Phospho-eIF4EBP1 (T70) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
功能
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
