产品名称
Phospho-Tuberin (T1462) (19F18) Rabbit Monoclonal Antibody
别名
LAM; PPP1R160; Protein phosphatase 1, regulatory subunit 160; tsc2; TSC4; TSC4, formerly; Tuberin; Tuberous sclerosis 2;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P49815
稀释度
WB 1:500~1:2000 IHC 1:50~1:200
注意事项
Phospho-Tuberin (T1462) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta
细胞定位
Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes
功能
In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:
12271141, PubMed:
28215400). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:
15340059). May also play a role in microtubule-mediated protein transport (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity).
