产品名称
KCNB2 Rabbit Polyclonal Antibody
蛋白名称
Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q92953
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q92953/entry
Mouse Swissprot No.
A6H8H5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/A6H8H5
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q63099
免疫原
Synthesized peptide derived from human protein . at AA range: 170-250
特异性
KCNB2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008],
细胞定位
Cell membrane ; Multi-pass membrane protein . Perikaryon . Cell projection, dendrite . Localized uniformly throughout cell bodies and dendrites. Colocalizes with KCNB1 to high-density somatodendritic clusters on cortical pyramidal neurons. .
功能
domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,domain:The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.,function:Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.,PTM:Phosphorylated .,similarity:Belongs to the potassium channel family. B (Shab) subfamily.,subunit:Heteromultimer with KCNS1, KCNS2 and KCNS3.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
