RM7186

Acetyl Coenzyme A Carboxylase (14O6) Rabbit Monoclonal Antibody

ACAC; ACACA; ACC alpha; ACC1; ACCA; Acetyl Coenzyme A; Biotin carboxylase;

Affinity-chromatography

常规抗体

ACACA

ACAC, ACC1, ACCA

WB

Human

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

31

Q13085

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

266kDa

Rabbit IgG

Acetyl Coenzyme A Carboxylase Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed in brain, placenta, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver

Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5SWU9}

Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20952656, PubMed:20457939, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20952656, PubMed:20457939, PubMed:29899443).

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