产品名称
phospho-Phospholipase C gamma 1/PLC-gamma-1 (Y1253)(14A10) Rabbit Monoclonal Antibody
别名
PLC-148; PLC-II; PLC-gamma1; PLC1; PLCG-1; Phospholipase C-gamma-1;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P19174
免疫原
A synthetic peptide of human Phospholipase C gamma 1/PLC-gamma-1
稀释度
WB: 1:2000 ICC/IF: 1:50 FC: 1:20 IP: 1:20
注意事项
phospho-Phospholipase C gamma 1/PLC-gamma-1 (Y1253) is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.
功能
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:
17229814).
