产品名称
Phospho-BCAR1 (Y410) (17X7) Rabbit Monoclonal Antibody
别名
BCAR 1; Bcar1; Breast cancer anti estrogen resistance 1 Breast cancer anti-estrogen resistance protein 1; CAS; Cas scaffolding protein family member 1; CAS1; Cass1; Crk associated substrate; Crk associated substrate p130Cas; CRK-associated substrate; CRKAS; p130cas;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P56945
注意事项
Phospho-BCAR1 (Y410) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line
细胞定位
Cell junction, focal adhesion. Cytoplasm Cell projection, axon {ECO:0000250|UniProtKB:Q61140} Note=Unphosphorylated form localizes in the cytoplasm (By similarity) Localizes to focal adhesion sites following integrin engagement (By similarity). {ECO:0000250|UniProtKB:Q61140}
功能
Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:
12832404, PubMed:
12432078). Implicated in induction of cell migration and cell branching (PubMed:
12432078, PubMed:
12832404, PubMed:
17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity).
