产品名称
PSIP1 / LEDGF (14G8) Rabbit Monoclonal Antibody
别名
DFS70; LEDGF; p52; p75; PAIP; Psip1; PSIP2;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
O75475
稀释度
WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200
注意事项
PSIP1 / LEDGF Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions
细胞定位
Nucleus. Note=Remains chromatin-associated throughout the cell cycle
功能
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre- mRNA splicing. Cellular cofactor for lentiviral integration.
