产品名称
Phospho-ErbB2(Y1221 + Y1222) (11Z13) Rabbit Monoclonal Antibody
别名
CD340; CerbB2; Erb b2 receptor tyrosine kinase 2; ERBB2; HER2; Herstatin; Human epidermal growth factor receptor 2; MLN19; NEU; NGL; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; Tyrosine kinase type cell surface receptor HER2; V erb b2 avian erythroblastic leukemia viral oncogene homolog 2; V erb b2 avian erythroblastic leukemia viral oncoprotein 2;
纯度
Affinity-chromatography
蛋白名称
HER2, MLN19, NEU, NGL
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P04626
注意事项
Phospho-ErbB2(Y1221 + Y1222) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.
细胞定位
[Isoform 1]: Cell membrane; Single-pass type I membrane protein Early endosome. Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794). [Isoform 3]: Cytoplasm. Nucleus.
功能
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
