产品名称
GAS2 (4W7) Rabbit Monoclonal Antibody
别名
Gas2; Growth arrest specific 2;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
O43903
免疫原
A synthetic peptide of human GAS2
稀释度
WB: 1:1000 IHC: 1:100 IP: 1:20
注意事项
GAS2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen
细胞定位
Cytoplasm, cytoskeleton, stress fiber. Membrane {ECO:0000250|UniProtKB:P11862}; Peripheral membrane protein {ECO:0000250|UniProtKB:P11862} Note=Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth- arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles {ECO:0000250|UniProtKB:P11862}
功能
May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity).
