产品名称
Phospho-JAK1 (Y1034 + Y1035) (14S9) Rabbit Monoclonal Antibody
别名
JAK 1; JAK 1A; JAK 1B; JAK1; JAK1A; JAK1B; JTK3; historically have been referenced as Tyr1022 and Tyr1023 (Y1022 + Y1023);
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P23458
免疫原
A synthetic phosphopeptide corresponding to residues surrounding Tyr1022/Tyr1023 of human JAK1
稀释度
WB 1:500~1:2000 IHC 1:50~1:100
注意事项
Phospho-JAK1 (Y1034 + Y1035) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue
细胞定位
Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated
功能
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:
7615558, PubMed:
28111307, PubMed:
32750333, PubMed:
16239216). Kinase partner for the interleukin (IL)-2 receptor (PubMed:
11909529) as well as interleukin (IL)-10 receptor (PubMed:
12133952). Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed:
16239216, PubMed:
32750333).
