产品名称
CLPX Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10845
Human Swissprot No.
O76031
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O76031/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/270166
Mouse Swissprot No.
Q9JHS4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JHS4
Rat Gene Link
https://www.uniprot.org/uniprot/300786
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5U2U0
免疫原
Synthesized peptide derived from human CLPX AA range: 328-378
特异性
This antibody detects endogenous levels of CLPX at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is part of a protease found in mitochondria. This protease is ATP-dependent and targets specific proteins for degradation. The protease consists of two heptameric rings of the CLPP catalytic subunit sandwiched between two hexameric rings of the chaperone subunit encoded by this gene. Targeted proteins are unwound by this protein and then passed on to the CLPP subunit for degradation. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015],
组织表达
Higher expression in skeletal muscle and heart and to a lesser extent in liver, brain, placenta, lung, kidney and pancreas.
细胞定位
Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid.
功能
function:ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of clpP.,similarity:Belongs to the clpX chaperone family.,subunit:Heterodimer of clpP and clpX.,tissue specificity:Higher expression in skeletal muscle and heart and to a lesser extent in liver, brain, placenta, lung, kidney and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
