产品名称
PLXB1 Rabbit Polyclonal Antibody
基因名称
PLXNB1 KIAA0407 PLXN5 SEP
蛋白名称
Plexin-B1 (Semaphorin receptor SEP)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O43157
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O43157/entry
Mouse Swissprot No.
Q8CJH3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CJH3
免疫原
Synthesized peptide derived from human protein . at AA range: 90-170
特异性
PLXB1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
disease:Overexpressed and constitutively tyrosine phosphorylated in colon, liver, pancreas and gastric carcinoma cell lines. Overexpression increases MET activation and promotes invasive growth.,function:Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.,PTM:Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding.,PTM:Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding.,similarity:Belongs to the plexin family.,similarity:Contains 1 Sema domain.,similarity:Contains 3 IPT/TIG domains.,subunit:Monomer, and heterodimer with PLXNB2 after proteolytic processing. Binds RAC1 that has been activated by GTP binding. Interaction with SEMA4D promotes binding of cytoplasmic ligands. Binds PLXNA1 (By similarity). Binds ARHGEF11, ARHGEF12, ERBB2, MET, MST1R, RND1, NRP1 and NRP2.,tissue specificity:Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver.,
组织表达
Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver.
细胞定位
[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .; [Isoform 3]: Secreted .
功能
disease:Overexpressed and constitutively tyrosine phosphorylated in colon, liver, pancreas and gastric carcinoma cell lines. Overexpression increases MET activation and promotes invasive growth.,function:Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.,PTM:Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding.,PTM:Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding.,similarity:Belongs to the plexin family.,similarity:Contains 1 Sema domain.,similarity:Contains 3 IPT/TIG domains.,subunit:Monomer, and heterodimer with PLXNB2 after proteolytic processing. Binds RAC1 that has been activated by GTP binding. Interaction with SEMA4D promotes binding of cytoplasmic ligands. Binds PLXNA1 (By similarity). Binds ARHGEF11, ARHGEF12, ERBB2, MET, MST1R, RND1, NRP1 and NRP2.,tissue specificity:Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
