产品名称
CD275 (16R19) Rabbit Monoclonal Antibody
别名
B7H2; B7RP1; CD275; GL50; ICOSL; Icoslg; LICOS;
纯度
Affinity-chromatography
蛋白名称
B7H2, B7RP1, ICOSL, KIAA0653
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
O75144
免疫原
Recombinant protein of human ICOS Ligand
注意事项
CD275 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.
细胞定位
Cell membrane; Single-pass type I membrane protein
功能
Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).
