产品名称
PLXA2 Rabbit Polyclonal Antibody
基因名称
PLXNA2 KIAA0463 OCT PLXN2 UNQ209/PRO235
蛋白名称
Plexin-A2 (Semaphorin receptor OCT)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O75051
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75051/entry
Mouse Swissprot No.
P70207
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P70207
免疫原
Synthesized peptide derived from human protein . at AA range: 600-680
特异性
PLXA2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008],
组织表达
Detected in fetal brain.
细胞定位
Cell membrane ; Single-pass type I membrane protein .
功能
function:Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.,similarity:Belongs to the plexin family.,similarity:Contains 1 Sema domain.,similarity:Contains 4 IPT/TIG domains.,subunit:Interacts directly with NRP1 and NRP2.,tissue specificity:Detected in fetal brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
