RM7065

RNF7 (10Y4) Rabbit Monoclonal Antibody

CKBBP1; Rbx2; RNF7; ROC2; SAG;

Affinity-chromatography

常规抗体

RNF7

RBX2, ROC2, SAG

WB

Human,Mouse,Rat

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

9616

Q9UBF6

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

13kDa

Rabbit IgG

RNF7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed in heart, liver, skeletal muscle and pancreas. At very low levels expressed in brain, placenta and lung

Cytoplasm. Nucleus

Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:10851089). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). Through the RING- type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.

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