产品名称
PREPL (8Q5) Rabbit Monoclonal Antibody
别名
prepl; Prolyl endopeptidase-like;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q4J6C6
免疫原
A synthetic peptide of human PPCEL/PREPL
稀释度
WB: 1:1000 ICC/IF: 1:200 FC: 1:20 IP: 1:20
注意事项
PREPL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in pyramidal neurons of the temporal cortex and neocortex (at protein level) (PubMed:23485813). Widely expressed (PubMed:15913950, PubMed:16385448). Expressed at higher level in brain, skeletal muscle, heart and kidney (PubMed:15913950, PubMed:16385448). Expressed at the endplates in the neuromuscular junction (PubMed:24610330).
细胞定位
Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q8C167}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8C167}. Golgi apparatus {ECO:0000250|UniProtKB:Q8C167}. Nucleus Note=Co-localizes with AP-1 in the trans-Golgi network (By similarity) Co-localizes with MAP2 and ACTB on the cytoskeleton (By similarity) Co-localizes with STX6 and GOSR2 at the Golgi apparatus (By similarity). {ECO:0000250|UniProtKB:Q8C167}
功能
Serine peptidase whose precise substrate specificity remains unclear (PubMed:
16143824, PubMed:
16385448, PubMed:
28726805). Does not cleave peptides after a arginine or lysine residue (PubMed:
16143824). Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex (PubMed:
23321636). May play a role in the regulation of synaptic vesicle exocytosis (PubMed:
24610330).
