产品名称
Meckelin (4U13) Rabbit Monoclonal Antibody
别名
JBTS6; MKS3; NPHP11; TMEM67; TNEM67;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q5HYA8
免疫原
A synthetic peptide of human Meckelin
稀释度
WB: 1:1000 IHC: 1:50 ICC/IF: 1:200 FC: 1:50
注意事项
Meckelin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Widely expressed in adult and fetal tissues. Expressed at higher level in spinal cord.
细胞定位
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, cilium Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:22121117).
功能
Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC).
