产品名称
GNAQ (17I9) Rabbit Monoclonal Antibody
别名
CMC1; G alpha Q; G protein alpha Q ; GAQ; GNAQ;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P50148
免疫原
Recombinant protein of human GNAQ
稀释度
WB: 1:1000 IHC: 1:200 FC: 1:20 IP: 1:20
注意事项
GNAQ Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Predominantly expressed in ovary, prostate, testis and colon. Down-regulated in the peripheral blood lymphocytes (PBLs) of rheumatoid arthritis patients (at protein level)
细胞定位
Cell membrane; Lipid-anchor. Golgi apparatus. Nucleus {ECO:0000250|UniProtKB:P21279} Nucleus membrane {ECO:0000250, ECO:0000250|UniProtKB:P21279} Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes {ECO:0000250|UniProtKB:P21279}
功能
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM- derived neutrophils and dendritic cells (in vitro) (By similarity). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs).
