产品名称
SLC27A4 (1C18) Rabbit Monoclonal Antibody
别名
ACSVL4; FATP4; IPS; S27A4; SLC27 A4;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q6P1M0
免疫原
Recombinant protein of human SLC27A4/FATP4
稀释度
WB: 1:1000 IHC: 1:50 ICC/IF: 1:100 IP: 1:50
注意事项
SLC27A4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tissue (PubMed:24269233, PubMed:9878842). Expressed in brain gray matter (PubMed:21395585).
细胞定位
Endoplasmic reticulum membrane; Multi-pass membrane protein
功能
Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane (PubMed:
12556534, PubMed:
21395585). Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs) (PubMed:
24269233). Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis (By similarity). Probably involved in fatty acid transport across the blood barrier (PubMed:
21395585). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity).
