产品名称
Nesprin3 (5G4) Rabbit Monoclonal Antibody
别名
C14orf49; Nesp3; Nesprin 3; NET53; SYNE3;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q6ZMZ3
免疫原
Recombinant protein of human Nesprin3
注意事项
Nesprin3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in aortic endothelial cells (at protein level).
细胞定位
Nucleus outer membrane; Single-pass type IV membrane protein. Nucleus envelope. Rough endoplasmic reticulum
功能
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.
