RM7005

NOLC1 (17R1) Rabbit Monoclonal Antibody

NOLC1; NOPP130; Nopp140; NS5ATP13; Nucleolar phosphoprotein p130; P130;

Affinity-chromatography

常规抗体

NOLC1

WB

Human,Mouse

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

9221

Q14978

A synthetic peptide of human NOLC1

WB: 1:2000-1:10000 IHC: 1:20 ICC/IF: 1:100 FC: 1:50

110kDa

74kDa

Rabbit IgG

NOLC1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nucleolus and the cytoplasm. At telophase it begins to assemble into granular-like pre-nucleolar bodies which are subsequently relocated to nucleoli at the early G1-phase.

Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786).

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