产品名称
TAOK1 (16B9) Rabbit Monoclonal Antibody
别名
hKFC B; MAP3K16; MARK kinase; MARKK; PSK2; STE20 like kinase; Taok1;
纯度
Affinity-chromatography
蛋白名称
KIAA1361, MAP3K16, MARKK
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q7L7X3
免疫原
A synthetic peptide of human TAOK1
注意事项
TAOK1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle
功能
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.
