产品名称
CLIC4 (11N17) Rabbit Monoclonal Antibody
别名
Chloride intracellular channel 4; Clic4; CLIC4L; HUH1; MC3S5; mtCLIC; p64H1;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q9Y696
免疫原
A synthetic peptide of human CLIC4
稀释度
WB: 1:2000-1:10000 IHC: 1:100 ICC/IF: 1:100 FC: 1:20 IP: 1:20
注意事项
CLIC4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle.
细胞定位
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane; Single- pass membrane protein. Nucleus matrix. Cell membrane; Single-pass membrane protein Mitochondrion. Cell junction. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles
功能
Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).
