产品名称
NTH1 (12T15) Rabbit Monoclonal Antibody
别名
hNTH1; NTH1; Nthl1; OCTS3;
纯度
Affinity-chromatography
基因名称
NTHL1 {ECO:0000255|HAMAP-Rule:MF_03183}
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P78549
免疫原
Recombinant protein of human NTH1
稀释度
WB: 1:1000 IHC: 1:20 ICC/IF: 1:20
注意事项
NTH1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Widely expressed with highest levels in heart and lowest levels in lung and liver.
细胞定位
Nucleus {ECO:0000255|HAMAP-Rule:MF_03183, ECO:0000269|PubMed:10882850, ECO:0000269|PubMed:12531031, ECO:0000269|PubMed:9611236}. Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03183, ECO:0000269|PubMed:9611236}
功能
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage (PubMed:
9927729). The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.
