RM6988

Septin 8 (18E13) Rabbit Monoclonal Antibody

SEP2; SEPT8; Septin8;

Affinity-chromatography

常规抗体

SEPTIN8

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

23176

Q92599

A synthetic peptide of human Septin 8

WB: 1:1000 IHC: 1:50 ICC/IF: 1:50 FC: 1:20 IP: 1:20

56kDa

56kDa

Rabbit IgG

Septin 8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Widely expressed, including in brain, heart and platelets; most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary.

Cytoplasm {ECO:0000250|UniProtKB:B0BNF1}. Cytoplasm, cytoskeleton. Cell junction, synapse {ECO:0000250|UniProtKB:B0BNF1}. Cell projection, axon {ECO:0000250|UniProtKB:B0BNF1}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:B0BNF1}. Cell junction, synapse, presynapse {ECO:0000250|UniProtKB:B0BNF1} Note=Expressed in axons of immature neurons, localizes to synapses in mature neurons (By similarity). In platelets, found in areas surrounding alpha-granules (PubMed:15116257) {ECO:0000250|UniProtKB:B0BNF1, ECO:0000269|PubMed:15116257}

Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (PubMed:15116257). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity).

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