产品名称
PLS3 Rabbit Polyclonal Antibody
蛋白名称
Phospholipid scramblase 3 (PL scramblase 3) (Ca(2+)-dependent phospholipid scramblase 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9NRY6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NRY6/entry
Mouse Swissprot No.
Q9JIZ9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JIZ9
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q6QBQ4
免疫原
Synthesized peptide derived from human protein . at AA range: 180-260
特异性
PLS3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
cofactor:Calcium.,function:May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.,similarity:Belongs to the phospholipid scramblase family.,tissue specificity:Expressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine and peripheral blood lymphocytes. Not detected in testis, brain and liver.,
组织表达
Expressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine and peripheral blood lymphocytes. Not detected in testis, brain and liver.
细胞定位
Mitochondrion membrane ; Single-pass type II membrane protein . Mitochondrion inner membrane ; Single-pass type II membrane protein . Nucleus . Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus. .
功能
cofactor:Calcium.,function:May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.,similarity:Belongs to the phospholipid scramblase family.,tissue specificity:Expressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine and peripheral blood lymphocytes. Not detected in testis, brain and liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
