产品名称
PARVA Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/55742
Human Swissprot No.
Q9NVD7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NVD7/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/57342
Mouse Swissprot No.
Q9EPC1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9EPC1
Rat Gene Link
https://www.uniprot.org/uniprot/57341
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9HB97
免疫原
Synthesized peptide derived from human PARVA AA range: 178-228
特异性
This antibody detects endogenous levels of PARVA at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival. [provided by RefSeq, Dec 2010],
组织表达
Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver.
细胞定位
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line . Constituent of focal adhesions. Associates with the actin cytoskeleton.
功能
function:Probably plays a role in the regulation of cell adhesion and cytoskeleton organization.,similarity:Belongs to the parvin family.,similarity:Contains 2 CH (calponin-homology) domains.,subcellular location:Constituent of focal adhesions.,subunit:Interacts with TGFB1I1 (By similarity). Interacts with integrin-linked protein kinase and probably with actin and the LD1 and LD4 motifs of PXN. Interacts with CDGAP.,tissue specificity:Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
