RM6983

SAFB (3B17) Rabbit Monoclonal Antibody

HAP; HET; SAFB; SAFB1;

Affinity-chromatography

常规抗体

SAFB

HAP, HET, SAFB1

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

6294

Q15424

A synthetic peptide of human SAFB

WB: 1:1000 IHC: 1:100 ICC/IF: 1:20

150kDa

103kDa

Rabbit IgG

SAFB Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Ubiquitous. Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines

Nucleus

Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity).

现货