产品名称
PLS2 Rabbit Polyclonal Antibody
蛋白名称
Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9NRY7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NRY7/entry
Mouse Swissprot No.
Q9DCW2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9DCW2
免疫原
Synthesized peptide derived from human protein . at AA range: 90-170
特异性
PLS2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the phospholipid scramblase family. Phospholipid scramblases are membrane proteins that mediate calcium-dependent, non-specific movement of plasma membrane phospholipids and phosphatidylserine exposure. The encoded protein contains a low affinity calcium binding motif and may play a role in blood coagulation and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011],
组织表达
Expression of isoform 1 seems restricted to testis.
细胞定位
Membrane ; Single-pass type II membrane protein .; [Isoform 1]: Nucleus .
功能
cofactor:Calcium.,function:May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.,online information:Scramblase entry,similarity:Belongs to the phospholipid scramblase family.,tissue specificity:Exclusively expressed in testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
