RM6974

PNK / PNKP (19Q2) Rabbit Monoclonal Antibody

DEM1; EIEE10; MCSZ; PNK1; Pnkp; PNKP DNA kinase;

Affinity-chromatography

常规抗体

PNKP {ECO:0000303|PubMed:10446192, ECO:0000312|HGNC:HGNC:9154}

WB

Human

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

11284

Q96T60

WB 1:500~1:2000 IHC 1:50~1:200 IP 1:50

57kDa

Rabbit IgG

PNK / PNKP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed in many tissues with highest expression in spleen and testis, and lowest expression in small intestine (PubMed:10446192). Expressed in higher amount in pancreas, heart and kidney and at lower levels in brain, lung and liver (PubMed:10446193)

Nucleus. Chromosome. Note=Localizes to site of double-strand breaks.

Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways (PubMed:10446192, PubMed:10446193, PubMed:15385968, PubMed:20852255, PubMed:28453785). Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone (PubMed:10446192, PubMed:10446193).

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