产品名称
PTPRR (17O4) Rabbit Monoclonal Antibody
别名
ECPTP; NC PTPCOM1; PTPBR7; PTPRQ; PTPRR; PTPSL; Receptor type tyrosine protein phosphatase R;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q15256
免疫原
A synthetic peptide of human PCPTP1
注意事项
PTPRR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta, prostate, small intestine and uterus
细胞定位
[Isoform Alpha]: Cell membrane; Single-pass type I membrane protein [Isoform Gamma]: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within the cytoplasm
功能
Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity).
