RM6969

UFD1L (6R6) Rabbit Monoclonal Antibody

UB fusion protein 1; UFD1; UFD1L;

Affinity-chromatography

常规抗体

UFD1

UFD1L

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

7353

Q92890

A synthetic peptide of human UFD1L

WB: 1:1000-1:5000 ICC/IF: 1:20 FC: 1:20

40kDa

35kDa

Rabbit IgG

UFD1L Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Found in adult heart, skeletal muscle and pancreas, and in fetal liver and kidney

Nucleus {ECO:0000250|UniProtKB:Q9ES53}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9ES53}

Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1- VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729).

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