产品名称
PLS1 Rabbit Polyclonal Antibody
蛋白名称
Phospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependent phospholipid scramblase 1) (Erythrocyte phospholipid scramblase) (MmTRA1b)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O15162
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O15162/entry
Mouse Swissprot No.
Q9JJ00
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JJ00
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P58195
免疫原
Synthesized peptide derived from human protein . at AA range: 170-250
特异性
PLS1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
cofactor:Calcium.,function:May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.,function:May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation.,induction:By phosphorylation by PKC. Induced by INFB1 in response to a viral infection.,online information:Scramblase entry,PTM:Known to be palmitoylated at one, yet undefined, site.,similarity:Belongs to the phospholipid scramblase family.,subunit:Interacts with ABL.,tissue specificity:Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle.,
组织表达
Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle.
细胞定位
Cell membrane ; Single-pass type II membrane protein . Cell membrane ; Lipid-anchor ; Cytoplasmic side. Nucleus . Cytoplasm . Cytoplasm, perinuclear region . Localizes to the perinuclear region in the presence of RELT (PubMed:22052202). Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus (PubMed:12564925). .
功能
cofactor:Calcium.,function:May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.,function:May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation.,induction:By phosphorylation by PKC. Induced by INFB1 in response to a viral infection.,online information:Scramblase entry,PTM:Known to be palmitoylated at one, yet undefined, site.,similarity:Belongs to the phospholipid scramblase family.,subunit:Interacts with ABL.,tissue specificity:Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
