产品名称
FPGS (8U2) Rabbit Monoclonal Antibody
别名
FOLC; Folylpoly gamma glutamate synthetase; FPGS; Tetrahydrofolate synthase;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q05932
免疫原
A synthetic peptide of human FPGS
稀释度
WB: 1:2000-1:10000 FC: 1:20
注意事项
FPGS Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
[Isoform 1]: Mitochondrion inner membrane. Mitochondrion matrix
功能
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.
