产品名称
BRAT1 (3S9) Rabbit Monoclonal Antibody
别名
BAAT1; brat1; C7orf27; RMFSL;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q6PJG6
免疫原
Recombinant protein of human BRAT1
稀释度
WB: 1:2000-1:10000 ICC/IF: 1:50 FC: 1:20 IP: 1:20
注意事项
BRAT1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Ubiquitously expressed.
细胞定位
Nucleus. Cytoplasm Note=Present at double strand breaks (DSBs)following ionizing radiation treatment. The ubiquitinated form localizes in the nucleus in a NDFIP1- dependent manner.
功能
Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed:
16452482, PubMed:
22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed:
25070371). Required for protein stability of MTOR and MTOR- related proteins, and cell cycle progress by growth factors (PubMed:
25657994).
