产品名称
PA21B Rabbit Polyclonal Antibody
基因名称
PLA2G1B PLA2 PLA2A PPLA2
蛋白名称
Phospholipase A2 (EC 3.1.1.4) (Group IB phospholipase A2) (Phosphatidylcholine 2-acylhydrolase 1B)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P04054
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P04054/entry
Mouse Swissprot No.
Q9Z0Y2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z0Y2
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P04055
免疫原
Synthesized peptide derived from human protein . at AA range: 70-150
特异性
PA21B Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013],
组织表达
Selectively expressed in pancreas, lung, liver and kidney. Also detected at lower levels in ovary and testis.
细胞定位
Secreted . Secreted from pancreatic acinar cells in its inactive form.
信号通路
Glycerophospholipid metabolism;Ether lipid metabolism;Arachidonic acid metabolism;Linoleic acid metabolism;alpha-Linolenic acid metabolism;MAPK_ERK_Growth;MAPK_G_Protein;Vascular smooth muscle contraction;VEGF;Fc epsilon RI;Long-term depression;GnRH;
功能
catalytic activity:Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.,cofactor:Binds 1 calcium ion per subunit.,function:PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.,similarity:Belongs to the phospholipase A2 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
