产品名称
PI3R6 Rabbit Polyclonal Antibody
蛋白名称
Phosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3-kinase gamma adapter protein of 87 kDa) (p84 PI3K adapter protein) (p84 PIKAP) (p87 PI3K adapter protein) (p87PIKAP)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q5UE93
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q5UE93/entry
Mouse Swissprot No.
Q3U6Q4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3U6Q4
免疫原
Synthesized peptide derived from human protein . at AA range: 280-360
特异性
PI3R6 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014],
细胞定位
Cytoplasm . Cell membrane ; Peripheral membrane protein . Translocated to the plasma membrane in a Ras-dependent manner. .
功能
function:Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by G beta gamma proteins.,subunit:Heterodimer of a catalytic subunit (PIK3CG) and a regulatory (PIK3R6) subunit. Also interacts with PDE3B and G beta gamma proteins. The binding of PIK3R6 to PIK3CG may exclude the binding of PIK3R5 to PIK3CG.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
