产品名称
NgR3 (8Q7) Rabbit Monoclonal Antibody
别名
NgR3; NGRH2; NGRL2; RTN4RL1;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q86UN2
免疫原
A synthetic peptide of human NgR3
稀释度
WB: 1:1000 ICC/IF: 1:50 FC: 1:20-1:100
注意事项
NgR3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen.
细胞定位
Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Perikaryon {ECO:0000250|UniProtKB:Q80WD0}. Cell projection {ECO:0000250|UniProtKB:Q80WD0}. Note=Localized to the surface of neurons, including axons. {ECO:0000250|UniProtKB:Q80WD0}
功能
Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:
22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:
22325200).
