RM6921

WDR1 (12E8) Rabbit Monoclonal Antibody

AIP1; NORI 1; wdr1;

Affinity-chromatography

常规抗体

WDR1

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

9948

O75083

A synthetic peptide of human WDR1

WB: 1:1000-1:5000 IHC: 1:20-1:50 ICC/IF: 1:20-1:50

66kDa

66kDa

Rabbit IgG

WDR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed in peripheral blood mononuclear cells (at protein level).

Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q5RKI0}. Cell projection, podosome. Cell junction

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458, PubMed:27557945, PubMed:29751004). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565).

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