产品名称
AK2 (2F12) Rabbit Monoclonal Antibody
别名
Adenylate kinase 2; ADK2; ak2;
纯度
Affinity-chromatography
基因名称
AK2 {ECO:0000255|HAMAP-Rule:MF_03168}
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P54819
免疫原
A synthetic peptide of human AK2
稀释度
WB: 1:1000 IHC: 1:50 ICC/IF: 1:100 IP: 1:20
注意事项
AK2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level)
细胞定位
Mitochondrion intermembrane space {ECO:0000255|HAMAP-Rule:MF_03168}
功能
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
