产品名称
PNK / PNKP (12Y10) Rabbit Monoclonal Antibody
别名
DEM1; EIEE10; MCSZ; PNK1; Pnkp;
纯度
Affinity-chromatography
基因名称
PNKP {ECO:0000303|PubMed:10446192, ECO:0000312|HGNC:HGNC:9154}
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q96T60
免疫原
A synthetic peptide of human PNK/PNKP
稀释度
WB: 1:1000 IHC: 1:20 IP: 1:20
注意事项
PNK / PNKP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in many tissues with highest expression in spleen and testis, and lowest expression in small intestine (PubMed:10446192). Expressed in higher amount in pancreas, heart and kidney and at lower levels in brain, lung and liver (PubMed:10446193)
细胞定位
Nucleus. Chromosome. Note=Localizes to site of double-strand breaks.
功能
Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways (PubMed:
10446192, PubMed:
10446193, PubMed:
15385968, PubMed:
20852255, PubMed:
28453785). Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone (PubMed:
10446192, PubMed:
10446193).
