产品名称
PI5L1 Rabbit Polyclonal Antibody
蛋白名称
Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 (PI(4)P 5-kinase-like protein 1) (PtdIns(4)P-5-kinase-like protein 1) (EC 2.7.1.68)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q5T9C9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q5T9C9/entry
Mouse Swissprot No.
Q6U7H8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6U7H8
免疫原
Synthesized peptide derived from human protein . at AA range: 270-350
特异性
PI5L1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
PIP5KL1 is a phosphoinositide kinase-like protein that lacks intrinsic lipid kinase activity but associates with type I PIPKs (see PIP5K1A; MIM 603275) and may play a role in localization of PIPK activity (Chang et al., 2004 [PubMed 14701839]).[supplied by OMIM, Jun 2009],
细胞定位
Cytoplasm. Membrane. Localized to large cytoplasmic vesicular structures. .
功能
catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.,caution:It is unsure if the enzyme has intrinsic kinase activity.,function:May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3.,similarity:Contains 1 PI5K domain.,subcellular location:Localized to large cytoplasmic vesicular structures.,subunit:Heterodimerizes with other type I phosphatidylinositol-4-phosphate 5-kinase.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
