Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria (PubMed:
14573790, PubMed:
17226776, PubMed:
18358005, PubMed:
29337693, PubMed:
31769662). Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response (PubMed:
14573790, PubMed:
17226776, PubMed:
18358005, PubMed:
12649167). Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis (PubMed:
14573790, PubMed:
17226776, PubMed:
18358005). Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases (PubMed:
18491232). Regulates cardiolipin de novo biosynthesis and its resynthesis (PubMed:
16939411).
