产品名称
UBA3 (12U15) Rabbit Monoclonal Antibody
别名
hUba3; NEDD8 activating enzyme E1C; uba3; UBE1C;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q8TBC4
免疫原
A synthetic peptide of human UBA3
注意事项
UBA3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Ubiquitously expressed.
功能
Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down- regulates steroid receptor activity. Necessary for cell cycle progression.
