产品名称
SARA (2P2) Rabbit Monoclonal Antibody
别名
hSARA; MADHIP; NSP; SAR1; SARA; SARA1; SMADIP; ZFYVE9;
纯度
Affinity-chromatography
蛋白名称
MADHIP, SARA, SMADIP
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
O95405
免疫原
A synthetic peptide of human SARA
稀释度
WB: 1:2000-1:10000 IHC: 1:50 FC: 1:20 IP: 1:20
注意事项
SARA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes
细胞定位
Cytoplasm. Early endosome membrane.
功能
Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.
