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DENN (5N10) Rabbit Monoclonal Antibody

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产品基本信息

产品货号
RM6860
产品名称
DENN (5N10) Rabbit Monoclonal Antibody
别名
IG20; MADD; RAB3GEP;
纯度
Affinity-chromatography
类别
常规抗体
基因名称
MADD {ECO:0000312|EMBL:AAB57735.1, ECO:0000312|HGNC:HGNC:6766}
推荐应用
WB
反应种属
Human,Mouse,Rat
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Gene ID
8567
Human Swissprot No.
Q8WXG6
免疫原
A synthetic peptide of human DENN
稀释度
WB: 1:1000 IHC: 1:50 ICC/IF: 1:20
参考分子量
220kDa
预测分子量
183kDa
同种型
Rabbit IgG
注意事项
DENN Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in testis, ovary, brain and heart (PubMed:8988362). Expressed in spleen, thymus, prostate, testis, ovary, small instestine and colon (PubMed:9115275). Expressed in liver (PubMed:9796103). [Isoform 2]: Expressed in the brain, breast, kidney, lung, ovary, pancreas, testis, uterus, stomach and thyroid [Isoform 4]: Expressed in the brain, breast, kidney, lung, ovary, pancreas, testis, uterus, stomach and thyroid [Isoform 6]: Not detected in the brain, breast, kidney, lung, ovary, pancreas, testis, uterus, stomach and thyroid
细胞定位
Cell membrane. Cytoplasm. Cell projection, axon {ECO:0000250|UniProtKB:Q80U28}
功能
Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:20937701, PubMed:18559336). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:20937701, PubMed:18559336). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in upregulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A- positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064).
期货
现货

Western blot analysis of DENN expression in HeLa cell lysate.

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