产品名称
CSN8 (17L13) Rabbit Monoclonal Antibody
别名
Cops8; CSN8; hCOP9; SGN8;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q99627
免疫原
A synthetic peptide of human COPS8
稀释度
WB: 1:1000-1:5000 IHC: 1:20-1:100 ICC/IF: 1:20-1:50 IP: 1:20-1:50
注意事项
CSN8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
功能
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
